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After 4 days, remove the used patch and apply a new one. 3 To help keep a schedule, try to change the patch on the same two days each week, 3-4 days apart Oxytrol (oxybutynin) is a transdermal patch used to treat an overactive bladder. Choose an area where you think the patch will be comfortable for you, where it will not be rubbed by tight clothing, and where it will be protected from sunlight by clothing Do not cut the patch into smaller pieces. Why would you use something less than effective, when you can get refills with your medical insurance card? Oxytrol For Women Overactive Bladder Transdermal Patch 8 Count. In a rotating fashion with the dose. The patch may not stick as well One new OXYTROL ® patch should be applied two times a week (every three to four days) according to your doctor's instructions. Always change OXYTROL® on the two days of the week you mark on your calendar. Dosage Forms and Strengths Transdermal System: 3. I'll definitely keep using this product. 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